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Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8650

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A 6-Point Subdivision Scheme and Its Applications for the Solution of 2nd Order Nonlinear Singularly Perturbed Boundary Value Problems
(Amer inst Mathematical Sciences-aims, 2020) Baleanu, Dumitru; Ejaz, Syeda Tehmina; Anju, Kaweeta; Ahmadian, Ali; Salahshour, Soheil; Ferrara, Massimiliano; Mustafa, Ghulam
In this paper, we first present a 6-point binary interpolating subdivision scheme (BISS) which produces a C-2 continuous curve and 4th order of approximation. Then as an application of the scheme, we develop an iterative algorithm for the solution of 2nd order nonlinear singularly perturbed boundary value problems (NSPBVP). The convergence of an iterative algorithm has also been presented. The 2nd order NSPBVP arising from combustion, chemical reactor theory, nuclear engineering, control theory, elasticity, and fluid mechanics can be solved by an iterative algorithm with 4th order of approximation.
Citation - WoS: 110
Citation - Scopus: 112
Active Laser Radar Systems With Stochastic Electromagnetic Beams in Turbulent Atmosphere
(Optica Publishing Group, 2008) Cai, Yangjian; Korotkova, Olga; Eyyuboglu, Halil T.; Baykal, Yahya
Propagation of stochastic electromagnetic beams through paraxial ABCD optical systems operating through turbulent atmosphere is investigated with the help of the ABCD matrices and the generalized Huygens-Fresnel integral. In particular, the analytic formula is derived for the cross-spectral density matrix of an electromagnetic Gaussian Schell-model (EGSM) beam. We applied our analysis for the ABCD system with a single lens located on the propagation path, representing, in a particular case, the unfolded double-pass propagation scenario of active laser radar. Through a number of numerical examples we investigated the effect of local turbulence strength and lens' parameters on spectral, coherence and polarization properties of the EGSM beam. (C) 2008 Optical Society of America
Citation - WoS: 12
Analysis of Dengue Transmission Dynamic Model by Stability and Hopf Bifurcation With Two-Time Delays
(Imr Press, 2023) Ambalarajan, Venkatesh; Sivakumar, Vinoth; Dhandapani, Prasantha Bharathi; Baleanu, Dumitru; Murugadoss, Prakash Raj
Background: Mathematical models reflecting the epidemiological dynamics of dengue infection have been discovered dating back to 1970. The four serotypes (DENV-1 to DENV-4) that cause dengue fever are antigenically related but different viruses that are transmitted by mosquitoes. It is a significant global public health issue since 2.5 billion individuals are at risk of contracting the virus. Methods: The purpose of this study is to carefully examine the transmission of dengue with a time delay. A dengue transmission dynamic model with two delays, the standard incidence, loss of immunity, recovery from infectiousness, and partial protection of the human population was developed. Results: Both endemic equilibrium and illness-free equilibrium were examined in terms of the stability theory of delay differential equations. As long as the basic reproduction number (R0) is less than unity, the illness-free equilibrium is locally asymptotically stable; however, when R0 exceeds unity, the equilibrium becomes unstable. The existence of Hopf bifurcation with delay as a bifurcation parameter and the conditions for endemic equilibrium stability were examined. To validate the theoretical results, numerical simulations were done. Conclusions: The length of the time delay in the dengue transmission epidemic model has no effect on the stability of the illness-free equilibrium. Regardless, Hopf bifurcation may occur depending on how much the delay impacts the stability of the underlying equilibrium. This mathematical modelling is effective for providing qualitative evaluations for the recovery of a huge population of afflicted community members with a time delay.
Citation - WoS: 183
Citation - Scopus: 193
Analysis of Reciprocity of Cos-Gaussian and Cosh-Gaussian Laser Beams in a Turbulent Atmosphere
(Optical Soc Amer, 2004) Eyyuboglu, HT; Baykal, Y
In a turbulent atmosphere, starting with a cos-Gaussian excitation at the source plane, the average intensity profile at the receiver plane is formulated. This average intensity profile is evaluated against the variations of link lengths, turbulence levels, two frequently used free-space optics wavelengths, and beam displacement parameters. We show that a cos-Gaussian beam, following a natural diffraction, is eventually transformed into a cosh-Gaussian beam. Combining our earlier results with the current findings, we conclude that cos-Gaussian and cosh-Gaussian beams act in a reciprocal manner after propagation in turbulence. The rates (paces) of conversion in the two directions are not the same. Although the conversion of cos-Gaussian beams to cosh-Gaussian beams can happen over a wide range of turbulence levels (low to moderate to high), the conversion of cosh-Gaussian beams to cos-Gaussian beams is pronounced under relatively stronger turbulence conditions. Source and propagation parameters that affect this reciprocity have been analyzed. (C) 2004 Optical Society of America.
Citation - WoS: 8
Citation - Scopus: 17
An Analysis on the Relationship Between Safety Awareness and Safety Behaviors of Healthcare Professionals, Ankara/Turkey
(Oxford Univ Press, 2020) Uzuntarla, Fatma; Kucukali, Serhat; Uzuntarla, Yasin
Objectives: This descriptive study aims to examine the relationship between the safety awareness of healthcare professional and their safety behaviors. Methods: The study was carried out on 418 healthcare professionals working in a training and research hospital in Ankara/Turkey. The survey method was used as data collection tool. The questionnaire consisted of 3 sections and 18 questions. First section consisted of questions on sociodemographic characteristics and, second section consisted of the awareness scale and third section consisted of safety behaviors scale. Results: The safety awareness and safety behaviors are scored on a scale from 1 (completely disagree) to 5 (completely agree). The safety awareness and safety behaviors has an average score of 3.85 +/- 0.81 and 3.56 +/- 0.82, respectively. The safety awareness and safety behavior levels of healthcare professionals were found to be high. Conclusion: A significant positive correlation was found between safety awareness and safety behaviors and it was concluded that the increase in safety awareness led to an increase in safety behavior.
Analytical Results for Positivity of Discrete Fractional Operators With Approximation of the Domain of Solutions
(Amer inst Mathematical Sciences-aims, 2022) O'Regan, Donal; Baleanu, Dumitru; Hamed, Y. S.; Elattar, Ehab E.; Mohammed, Pshtiwan Othman
We study the monotonicity method to analyse nabla positivity for discrete fractional operators of Riemann-Liouville type based on exponential kernels, where ((CFR)(c0)del F-theta)(t) > -epsilon Lambda(theta - 1) (del F)(c(0) + 1) such that (del F)(c(0) + 1) >= 0 and epsilon > 0. Next, the positivity of the fully discrete fractional operator is analyzed, and the region of the solution is presented. Further, we consider numerical simulations to validate our theory. Finally, the region of the solution and the cardinality of the region are discussed via standard plots and heat map plots. The figures confirm the region of solutions for specific values of epsilon and theta.
Citation - WoS: 26
Citation - Scopus: 31
Asymptotic Solutions of Fractional Interval Differential Equations With Nonsingular Kernel Derivative
(Amer inst Physics, 2019) Ahmadian, A.; Salimi, M.; Ferrara, M.; Baleanu, D.; Salahshour, S.
Realizing the behavior of the solution in the asymptotic situations is essential for repetitive applications in the control theory and modeling of the real-world systems. This study discusses a robust and definitive attitude to find the interval approximate asymptotic solutions of fractional differential equations (FDEs) with the Atangana-Baleanu (A-B) derivative. In fact, such critical tasks require to observe precisely the behavior of the noninterval case at first. In this regard, we initially shed light on the noninterval cases and analyze the behavior of the approximate asymptotic solutions, and then, we introduce the A-B derivative for FDEs under interval arithmetic and develop a new and reliable approximation approach for fractional interval differential equations with the interval A-B derivative to get the interval approximate asymptotic solutions. We exploit Laplace transforms to get the asymptotic approximate solution based on the interval asymptotic A-B fractional derivatives under interval arithmetic. The techniques developed here provide essential tools for finding interval approximation asymptotic solutions under interval fractional derivatives with nonsingular Mittag-Leffler kernels. Two cases arising in the real-world systems are modeled under interval notion and given to interpret the behavior of the interval approximate asymptotic solutions under different conditions as well as to validate this new approach. This study highlights the importance of the asymptotic solutions for FDEs regardless of interval or noninterval parameters. Published under license by AIP Publishing.
Citation - WoS: 53
Citation - Scopus: 58
Average Intensity and Spreading of an Elegant Hermite-Gaussian Beam in Turbulent Atmosphere
(Optical Soc Amer, 2009) Yuan, Yangsheng; Cai, Yangjian; Qu, Jun; Eyyuboglu, Halil T.; Baykal, Yahya
The propagation of an elegant Hermite-Gaussian beam (EHGB) in turbulent atmosphere is investigated. Analytical propagation formulae for the average intensity and effective beam size of an EHGB in turbulent atmosphere are derived based on the extended Huygens-Fresnel integral. The corresponding results of a standard Hermite-Gaussian beam (SHGB) in turbulent atmosphere are also derived for the convenience of comparison. The intensity and spreading properties of EHGBs and SHGBs in turbulent atmosphere are studied numerically and comparatively. It is found that the propagation properties of EHGBs and SHGBs are much different from their properties in free space, and the EHGB and SHGB with higher orders are less affected by the turbulence. What's more, the SHGB spreads more rapidly than the EHGB in turbulent atmosphere under the same conditions. Our results will be useful in long-distance free-space optical communications. (C) 2009 Optical Society of America
Citation - WoS: 113
Citation - Scopus: 116
Average Irradiance and Polarization Properties of a Radially or Azimuthally Polarized Beam in a Turbulent Atmosphere
(Optical Soc Amer, 2008) Cai, Yangjian; Lin, Qiang; Eyyuboglu, Halil T.; Baykal, Yahya
Analytical formulas are derived for the average irradiance and the degree of polarization of a radially or azimuthally polarized doughnut beam (PDB) propagating in a turbulent atmosphere by adopting a beam coherence-polarization matrix. It is found that the radial or azimuthal polarization structure of a radially or azimuthally PDB will be destroyed (i.e., a radially or azimuthally PDB is depolarized and becomes a partially polarized beam) and the doughnut beam spot becomes a circularly Gaussian beam spot during propagation in a turbulent atmosphere. The propagation properties are closely related to the parameters of the beam and the structure constant of the atmospheric turbulence. (C) 2008 Optical Society of America.
Citation - WoS: 8
Citation - Scopus: 9
Certain Fractional Integral Formulas Involving the Product of Generalized Bessel Functions
(Hindawi Ltd, 2013) Agarwal, P.; Purohit, S. D.; Baleanu, D.
We apply generalized operators of fractional integration involving Appell's function F-3(.) due to Marichev-Saigo-Maeda, to the product of the generalized Bessel function of the first kind due to Baricz. The results are expressed in terms of the multivariable generalized Lauricella functions. Corresponding assertions in terms of Saigo, Erdelyi-Kober, Riemann-Liouville, and Weyl type of fractional integrals are also presented. Some interesting special cases of our two main results are presented. We also point out that the results presented here, being of general character, are easily reducible to yield many diverse new and known integral formulas involving simpler functions.
Citation - WoS: 39
Citation - Scopus: 48
Chaotic Attractors With Fractional Conformable Derivatives in the Liouville-Caputo Sense and Its Dynamical Behaviors
(Mdpi, 2018) Baleanu, Dumitru; Tchier, Fairouz; Solis Perez, Jesus Emmanuel; Francisco Gomez-Aguilar, Jose
This paper deals with a numerical simulation of fractional conformable attractors of type Rabinovich-Fabrikant, Thomas' cyclically symmetric attractor and Newton-Leipnik. Fractional conformable and beta-conformable derivatives of Liouville-Caputo type are considered to solve the proposed systems. A numerical method based on the Adams-Moulton algorithm is employed to approximate the numerical simulations of the fractional-order conformable attractors. The results of the new type of fractional conformable and beta-conformable attractors are provided to illustrate the effectiveness of the proposed method.
Citation - WoS: 6
Citation - Scopus: 6
Characteristic Features of Thermoluminescence in Neodymium-Doped Gallium Sulfide
(Wiley, 2018) Isik, M.; Ahmedova, F.; Guseinov, A.; Gasanly, N.; Guler, I.
The thermoluminescence (TL) of neodymium-doped gallium sulfide (GaS:Nd) single crystals was measured from 10 K to room temperature with various heating rates between 0.2 and 1.0 K/sec. Two peaks centered at 70.9 K and 116.0 K were observed when using a heating rate of 0.8 K/sec. Initial rise and curve fitting methods were used to obtain information on trap activation energies. Activation energies of 94 and 216 meV were found for two analyzable peaks. The heating rate dependencies of TL intensities revealed that one of the observed peaks showed normal behavior according to the one trap-one recombination model, whereas the other model showed anomalous heating rate behavior. TL experiments were also carried out at different illumination temperatures from 10 to 32 K; maximum peak temperature remained almost the same at various illumination temperatures. This behavior indicated that the revealed trapping centers are single, discrete levels. The TL glow curves of undoped GaS crystals were also investigated and the effect of Nd doping on the TL characteristics of crystals is discussed in the manuscript.
Citation - WoS: 15
Citation - Scopus: 16
Characterization of Ti6al7nb Alloy Foams Surface Treated in Aqueous Naoh and Cacl2 Solutions
(Elsevier Science Bv, 2016) Esen, Ziya; Bor, Sakir; Butev, Ezgi
Ti6Al7Nb alloy foams having 53-73% porosity were manufactured via evaporation of magnesium space holders. A bioactive 1 mu m thick sodium hydrogel titanate layer, NaxH2-xTiyO2y+1., formed after 5 M NaOH treatment, was converted to crystalline sodium titanate, Na2TiyO2y+1, as a result of post-heat treatment. On the other hand, subsequent CaCl2 treatment of NaOH treated specimens induced calcium titanate formation. However, heat treatment of NaOH-CaCl2 treated specimens led to the loss of calcium and disappearance of the titanate phase. All of the aforementioned surface treatments reduced yield strengths due to the oxidation of the cell walls of the foams, while elastic moduli remained mostly unchanged. Accordingly, equiaxed dimples seen on the fracture surfaces of as-manufactured foams turned into relatively flat and featureless fracture surfaces after surface treatments. On the other hand, Ca- and Na-rich coating preserved their mechanical stabilities and did not spall during fracture. The relation between mechanical properties of foams and macro-porosity fraction were found to obey a power law. The foams with 63 and 73% porosity met the desired biocompatibility requirements with fully open pore structures and elastic moduli similar to that of bone. In vitro tests conducted in simulated body fluid (SBF) showed that NaOH-heat treated surfaces exhibit the highest bioactivity and allow the formation of Ca-P rich phases having Ca/P ratio of 1.3 to form within 5 days. Although Ca-P rich phases formed only after 15 days on NaOH-CaCl2 treated specimens, the Ca/P ratio was closer to that of apatite found in bone. (C) 2016 Elsevier Ltd. All rights reserved.
Citation - WoS: 34
Citation - Scopus: 43
Clinoptilolite/Pcl-peg-pcl Composite Scaffolds for Bone Tissue Engineering Applications
(Sage Publications Ltd, 2017) Pazarceviren, Engin; Erdemli, Ozge; Keskin, Dilek; Tezcaner, Aysen
The aim of this study was to prepare and characterize highly porous clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) composite scaffolds. Scaffolds with different clinoptilolite contents (10% and 20%) were fabricated with reproducible solvent-free powder compression/particulate leaching technique. The scaffolds had interconnective porosity in the range of 55-76%. Clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)poly(epsilon-caprolactone) scaffolds showed negligible degradation within eight weeks and displayed less water uptake and higher bioactivity than poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) scaffolds. The presence of clinoptilolite improved the mechanical properties. Highest compressive strength (5.6 MPa) and modulus (114.84 MPa) were reached with scaffold group containing 20% clinoptilolite. In vitro protein adsorption capacity of the scaffolds was also higher for clinoptilolite/poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) scaffolds. These scaffolds had 0.95 mg protein/g scaffold adsorption capacity and also higher osteoinductivity in terms of enhanced ALP, OSP activities and intracellular calcium deposition. Stoichiometric apatite deposition (Ca/P = 1.686) was observed during cellular proliferation analysis with human fetal osteoblasts cells. Thus, it can be suggested that clinoptilolite/poly(epsilon-caprolactone)poly(ethylene glycol)-poly(epsilon-caprolactone) composite scaffolds could be promising carriers for enhancement of bone regeneration in bone tissue engineering applications.
Citation - WoS: 8
Citation - Scopus: 8
Comparative Analysis on Wavelet-Based Detection of Finite Duration Low-Amplitude Signals Related To Ventricular Late Potentials
(Iop Publishing Ltd, 2004) Mousa, A; Yilmaz, A
Ventricular late potentials (VLPs) are considered as a noninvasive marker of patients with myocardial infarction, who are prone to the development of ventricular tachycardia. This paper investigates the effects of variations in physical properties of myocardial infarcts in terms of their effects on the parametric variations in VLP analysis. A sufficiently large set of signals underlining the behavior of physical parameters was employed to represent the effect of physical size, position, orientation and type of infarct. The approximated signals are variations from real electrocardiography signals by adding potentials representing late potentials based on duration, frequency, amplitude and position. The aim is not to exactly model VLP but rather to generate an approximate set of signals to examine the performance of the standard methods for different possibilities in infarct dynamics. We investigate some of the detection approaches together with their related assumptions, and try to pinpoint the drawbacks and inaccuracies of these methods and also their assumptions. The three widely accepted criteria-QRS duration, root-mean-square and duration of the signal at the end of QRS for VLP detection-were used in the investigation. Results from the application of these parameters to the set of signals are presented. In addition we investigate the physical nature of an infarct and list a number of possible reasons that might be the cause of a low success rate for the detection of additive potentials. To improve the performance of the common methods, two more wavelet transform parameters are added to those of the standard methods. The method derived from this analysis is presented as an alternative means for the detection of late signals named as delayed potentials, a more general class that includes VLP as a subset.
Citation - WoS: 51
Citation - Scopus: 56
Comparative Study of the Continuous Wavelet Transform, Derivative and Partial Least Squares Methods Applied To the Overlapping Spectra for the Simultaneous Quantitative Resolution of Ascorbic Acid and Acetylsalicylic Acid in Effervescent Tablets
(Elsevier Science Bv, 2005) Ozdemir, A; Baleanu, D; Dinç, E
The simultaneous spectrophotometric determination of ascorbic acid (AA) and acetylsalicylic acid (ASA) in effervescent tablets in the presence of the overlapping spectra was accomplished by the continuous wavelet transform (CWT), derivative spectrophotometry (DS) and partial least squares (PLS) approaches without using any chemical pre-treatment. CWT and DS calibration equations for AA and ASA were obtained by measuring the CWT and DS amplitudes corresponding to zero-crossing points of spectra obtained by plotting continuous wavelet coefficients and first-derivative absorbance values versus the wavelengths, respectively. The PLS calibration was constructed by using the concentration set and its full absorbance data consisting of 850 points from 220 to 305 urn in the range of 210-310 nun. These three methods were tested by analyzing the synthetic mixtures of the above drugs and they were applied to the real samples containing two commercial pharmaceutical preparations of subjected drugs. A comparative study was carried out by using the experimental results obtained from three analytical methodologies and precise and accurate results were obtained. (c) 2004 Published by Elsevier B.V.
Citation - WoS: 31
Citation - Scopus: 32
A Comparative Study on Biodegradation and Mechanical Properties of Pressureless Infiltrated Ti/Ti6al4v-mg Composites
(Elsevier Science Bv, 2016) Karakas, M. Serdar; Esen, Ziya; Butev, Ezgi
The mechanical response and biodegradation behavior of pressureless Mg-infiltrated Ti-Mg and Ti6Al4V-Mg composites were investigated by compression and simulated body fluid immersion tests, respectively. Prior porous preforms were surrounded uniformly with magnesium as a result of infiltration and the resultant composites were free of secondary phases and intermetallics. Although the composites' compressive strengths were superior compared to bone, both displayed elastic moduli similar to that of cortical bone and had higher ductility with respect to their starting porous forms. However, Ti-Mg composites were unable to preserve their mechanical stabilities during in-vitro tests such that they fractured in multiple locations within 15 days of immersion. The pressure generated by H-2 due to rapid corrosion of magnesium caused failure of the Ti-Mg composites through sintering necks. On the other hand, the galvanic effect seen in Ti6Al4V-Mg was less severe compared to that of Ti-Mg. The degradation rate of magnesium in Ti6Al4V-Mg was slower, and the composites were observed to be mechanically stable and preserved their integrities over the entire 25-day immersion test. Both composites showed bioinert and biodegradable characteristics during immersion tests and magnesium preferentially corroded leaving porosity behind while Ti/Ti6Al4V remained as a permanent scaffold. The porosity created by degradation of magnesium was refilled by new globular agglomerates. Mg(OH)(2) and CaHPO4 phases were encountered during immersion tests while MgCl2 was detected during only the first 5 days. Both composites were classified as bioactive since the precipitation of CaHPO4 phase is known to be precursor of hydroxyapatite formation, an essential requirement for an artificial material to bond to living bone. (C) 2016 Elsevier Ltd. All rights reserved.
Citation - WoS: 3
Citation - Scopus: 4
Comparison of Classroom Furniture To Anthropometric Measures of Turkish Middle School Students
(Ios Press, 2021) Erdogan, Filiz Celikci; Satir, Benhur
BACKGROUND: The match between classroom furniture and students' anthropometry is an important factor in students' academic performance. OBJECTIVE: Our aim was to investigate the ergonomic suitability of the classroom furniture to the students, and to propose design suggestions for both desks and chairs. METHODS: We analyzed the ergonomics of classroom furniture that students aged 10-14 years old in Turkey currently use. To this end, we selected Maltepe Primary Education School, one of the largest schools in the cankaya district of Turkey's capital city, Ankara, in which to conduct the study. A sample of 119 students was selected, and seven anthropometric measurements were taken for each of these students. We then calculated five relationships between the dimensions of the furniture and the students' anthropometric measures. RESULTS: We observed high levels of mismatch rates, with an average of 66.6% and high values of over 95% for the relations of two furniture measures, seat depth (related with buttock-popliteal length) and seat-to-desk height (related with elbow height, sitting). Each anthropometric measure was applied a fit probability distribution, and based on those distributions; we suggested the most appropriate classroom furniture dimensions in order to maximize suitability of the furniture to the anthropometric measures in terms of fixed-size (i.e., non-adjustable) classroom furniture. CONCLUSIONS: High mismatch rates can be reduced by 52.0% on average based on the classroom furniture dimensions suggested in this study.
Citation - WoS: 12
Citation - Scopus: 11
A Computational Study of a Stochastic Fractal-Fractional Hepatitis B Virus Infection Incorporating Delayed Immune Reactions Via the Exponential Decay
(Amer inst Mathematical Sciences-aims, 2022) Rashid, Saima; Jarad, Fahd; Al Qurashi, Maysaa
Recently, researchers have become interested in modelling, monitoring, and treatment of hepatitis B virus infection. Understanding the various connections between pathogens, immune systems, and general liver function is crucial. In this study, we propose a higher-order stochastically modified delay differential model for the evolution of hepatitis B virus transmission involving defensive cells. Taking into account environmental stimuli and ambiguities, we presented numerical solutions of the fractal-fractional hepatitis B virus model based on the exponential decay kernel that reviewed the hepatitis B virus immune system involving cytotoxic T lymphocyte immunological mechanisms. Furthermore, qualitative aspects of the system are analyzed such as the existence-uniqueness of the non-negative solution, where the infection endures stochastically as a result of the solution evolving within the predetermined system's equilibrium state. In certain settings, infection-free can be determined, where the illness settles down tremendously with unit probability. To predict the viability of the fractal-fractional derivative outcomes, a novel numerical approach is used, resulting in several remarkable modelling results, including a change in fractional-order delta with constant fractal-dimension pi, delta with changing pi, and delta with changing both delta and pi. White noise concentration has a significant impact on how bacterial infections are treated.
Citation - WoS: 21
Citation - Scopus: 22
Computerized Detection and Segmentation of Mitochondria on Electron Microscope Images
(Wiley, 2012) Tasel, S. F.; Perkins, G.; Martone, M. E.; Gurcan, M. N.; Mumcuoglu, E. U.; Hassanpour, R.
Mitochondrial function plays an important role in the regulation of cellular life and death, including disease states. Disturbance in mitochondrial function and distribution can be accompanied by significant morphological alterations. Electron microscopy tomography (EMT) is a powerful technique to study the 3D structure of mitochondria, but the automatic detection and segmentation of mitochondria in EMT volumes has been challenging due to the presence of subcellular structures and imaging artifacts. Therefore, the interpretation, measurement and analysis of mitochondrial distribution and features have been time consuming, and development of specialized software tools is very important for high-throughput analyses needed to expedite the myriad studies on cellular events. Typically, mitochondrial EMT volumes are segmented manually using special software tools. Automatic contour extraction on large images with multiple mitochondria and many other subcellular structures is still an unaddressed problem. The purpose of this work is to develop computer algorithms to detect and segment both fully and partially seen mitochondria on electron microscopy images. The detection method relies on mitochondria's approximately elliptical shape and double membrane boundary. Initial detection results are first refined using active contours. Then, our seed point selection method automatically selects reliable seed points along the contour, and segmentation is finalized by automatically incorporating a live-wire graph search algorithm between these seed points. In our evaluations on four images containing multiple mitochondria, 52 ellipses are detected among which 42 are true and 10 are false detections. After false ellipses are eliminated manually, 14 out of 15 fully seen mitochondria and 4 out of 7 partially seen mitochondria are successfully detected. When compared with the segmentation of a trained reader, 91% Dice similarity coefficient was achieved with an average 4.9 nm boundary error.

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