Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8651
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Article Simultaneous Determination of Hydrochlorotiazide and Olmesartan Modoxomil in a Binary Mixture by the Calibrations of the Spectral Linear Regression Equations(Chiminform Data S A, 2012) Dinc, Erdal; Baleanu, Dumitru; Buker, Eda; Baleanu, Dumitru; MatematikTwo new approaches were proposed for the quantitative analysis of the commercial samples consisting of hydrochlorotiazide (HCT) and olmesartan modoxomil (OLM). The proposed bivariate calibration (BC) and multivariate linear regression calibration (MLRC) methods are based on the simultaneous use of the linear regression equations for each compound. The UV absorption spectra of calibration solutions in the linear concentration range of 1.0-16.0 mu g/mL for both HCT and OLM were recorded between the 200-300 nm wavelength regions. The individual linear regression equations of the subjected compounds were obtained by using the relationships between the concentration and absorbance values at the 62 wavelength points with the interval of 1.0 nm from 218 nm to 279 nm. The BC and MLRC model based linear regression equations were validated by analyzing the binary mixture samples containing HCT and OLM in the different concentration compositions. The proposed BC and MLRC approaches were found to be accurate, precise and rapid for the simultaneous determination of HCT and OLM in combined dosage form.Article Citation - WoS: 3Citation - Scopus: 3Linear Regression Functions-Multivariate Calibration Methods for the Determination of Two-Component Mixture(Chiminform Data S A, 2012) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Haliscelik, Ozan; Yavuz, Yunus E.; MatematikTwo numerical methods based on the linear regression functions were proposed for the simultaneous determinations of hydrochlorothiazide (HCT) and moexipril hydrochloride (MEP) in commercial samples. Standard series of hydrochlorothiazide and moexipril hydrochloride in the range of 4.0-14.0,mu g/mL and 6.0-16.0 mu g/mL were prepared in methanol. The UV spectra of the related standard series were recorded between 210.0-300.0 nm. The same recording procedure was applied to the samples of hydrochlorothiazide and moexipril hydrochloride. For the application of the bivariate calibration, 60 linear regression functions for each compound were obtained with an interval of Delta lambda=1.0 nm in the wavelength range of 220-280 nm. Kaiser technique was applied to the sensitivity matrices corresponding to the slopes of the linear regression functions for each wavelength pair We found that 220.0 nm and 269.0 nm were reported to be the optimal ones for the bivariate calibration method. The second method, the linear regression-multivariate calibration, is based on the use of 60 linear regression functions, without finding an optimal wavelength-pair set [4]. Both methods were validated by analyzing the synthetic mixtures of two above mentioned drugs. Recovery results were found as 103.0 and 101.0% for hydrochlorothiazide and 104.0 % and 102.0% for moexipril hydrochloride using the bivariate calibration and the linear regression function-multivariate calibration. These proposed calibration methods were sucessfuly applied to the quantification of the related compounds in the commercial tablets.Article Citation - WoS: 1Citation - Scopus: 1Simultaneous Spectrophotometric Determination of Levamizole and Oxyclozanide in Bolus by the Bivariate and Multivariate Linear Regression Calibration Methods(Chiminform Data S A, 2013) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikBivariate- and multivariate-calibration methods were improved for the simultaneous spectrophotometric determination of levamizole (LEV) and oxyclozanide (OXY) in commercial veterinary formulation without requiring chemical pretreatment and spectrophotometric graphical procedure. The bivariate calibration (BC) was constructed by using four linear regression equations at two-wavelength pair (218and 250 nm) for each compound. The selection of the optimal two-wavelength pair for the application of the BC method was performed by using the Kaiser's technique. The multivariate calibration (MC) was obtained by the simultaneous use of the 36 linear regression equations at the nineteen-wavelengths set from 216 nm to 254 nm in the spectral wavelength region of 200-290 nm. This MC method does not require any selection treatment of the optimal wavelength set. The BC and MC methods were validated by analyzing various synthetic binary mixtures and by using the standard addition technique. The successful determination results were reported for the quantitative estimation of the commercial veterinary product of the related active compounds.