Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8651
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Article Citation - WoS: 3Citation - Scopus: 2Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Tablets by Pcr and Pls Calibrations(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikPrincipal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of atorvastatin (ATO) and amlodipine (AML) in tablets without using a preliminary separation and even in presence of the overlapping spectra of the above mentioned compounds. For both PCR and PLS methods, a concentration set containing 17 different mixtures of ATO and AML in the linear concentration range of 0.0-20.0 mg/mL for both compounds was randomly prepared and then the absorbance values of the concentration set were measured at the 551 points-wavelength set with interval of Delta lambda=0.1 nm from 215 nm to 2 70 nm in the spectral range of 202320 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. These analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.Article Citation - WoS: 4Citation - Scopus: 4Fractional Wavelet Transform for the Quantitative Spectral Resolution of the Commercial Veterinary Preparations(Chiminform Data S A, 2011) Kambur, Murat; Baleanu, Dumitru; Narin, Ibrahim; Dinc, Erdal; Candir, Secil; Baleanu, Dumitru; MatematikFractional wavelet transform was applied to the quantitative spectral analysis of oxytetracycline and flunixin megluminein in a veterinary combination. A concentration set of 15 binary mixtures containing oxytetracycline and flunixin megluminein in the range of 4-36 mu g/mL oxytetracycline and 2-34 mu g/mL flunixin megluminein were processed by fractional wavelet transform (FWT) method. Partial least squares (PLS) and principal component regression (PCR) were applied to the FWT-coefficients to obtain FWT-PCR and FWT-PLS. The validity of the proposed FWT-PLS and FWT-PCR approaches were carried out by analyzing the synthetic binary mixtures of the related veterinary compounds. The proposed combined approaches were used for the quality control of the commercial veterinary formulation of compounds.Article Citation - WoS: 7Citation - Scopus: 9Simultaneous Spectrophotometric Determination of Chlordiazepoxide and Clidinium Bromide in Sugar Coated Tablets by Partial Least Squares, Principal Component Regression and Artificial Neutral Network(Chiminform Data S A, 2006) Dinc, Erdal; Baleanu, Dumitru; Dermis, Saadet; Baleanu, Dumitru; MatematikMultivariate spectrophotometric approaches based on namely partial least squares (PLS), principal component regression (PCR) and artificial neural network (ANN) were proposed for the simultaneous determination of chlordiazepoxide (CHP) and clidinium bromide (CLB) in sugar coated tablets without any chemical separation step. As an alternative approach, ANN was applied to obtain the calibration function between the training data matrix and its corresponding absorbance data matrix. A training set consisting of 24 mixture solutions in the concentration range of 0-25 mu g/mL CHP and 0-30 mg/mL was prepared in methanol and 0.1 M NaOH (60:40, v/v). PLS and PCR calibrations were constructed by using their chemometric algorithms dependent on the relationships training set and absorbance data matrix obtained in the spectral range of 210-400 nm. As a comparison approach, ANN was applied to the determination of the investigated drugs in their mixtures and the commercial pharmaceutical preparation to clarify interactions between the analyzed compounds and excipients in samples. The validation of these chemometric methods was carried out by analyzing the artificial mixtures containing CHP and CLB drugs. The mathematical treatments were performed by using Microsoft Excel, a neural network algorithm written in Matlab 7.0 and the PLS toolbox 3.5. These multivariate approaches were successfully applied to the real CHP and CLB samples. As a result, the proposed chemometric methods were found suitable for the quality control and routine analysis of two drugs in sugar coated tablets.Article Citation - WoS: 9Citation - Scopus: 10Spectrophotometric Simultaneous Determination of Levamisole and Triclabendazole in Tablets by Principal Component Regrassion and Partial Least Squares Chemometric Methods(Chiminform Data S A, 2008) Dinc, Erdal; Baleanu, Dumitru; Pektas, GozdePrincipal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of levamisole (LVM) and triclabendazole (TCB) in tablets without using a preliminary separation, even in presence of the overlapping spectra of the above compounds. For both PCR and PLS, a concentration set containing 25 different mixtures of LVM and TCB in the linear concentration range was symmetrically prepared and then the absorbance values of the concentration set were measured at the wavelength set with Delta lambda=0. 1nm in the spectral region of 225-322.3 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. Then, these analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.