Matematik Bölümü Yayın Koleksiyonu

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End date: 2009Subject: search.filters.subject.Binary Mixture

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  • Article
    Citation - WoS: 3
    Citation - Scopus: 5
    Simultaneous Determination of Quinapril and Hydrochlorothiazide in Tablets by Ratio Spectra Derivative Spectrophotometric and Chemometric Methods
    (Chiminform Data S A, 2007) Dinc, Erdal; Baleanu, Dumitru; Altynoz, Sacide; Baleanu, Dumitru; Matematik
    Simultaneous determination of quinapril (QA) and hydrochlorothiazide (HCT) in tablets were accomplished by ratio spectra first order derivative spectrophotometry (graphical method) and chemometric method (numerical method). Both methods do not require any chemical separation step. In the application of two analytical methods, the absorption spectra in the working range of 4.0-20.0 mu g/mL QA and 2.5-12.5 mu g/mL HCT were plotted in the wavelength range of 210-350 nm. In the graphical approach, the absorption spectra of QA and its binary mixtures in the selected spectral range of 210-280 nm were divided by the standard spectrum of 10 mu g/ mL HCT and their absorption spectra were obtained. In the similar way, the ratio spectra of HCT in the wavelength region of 210-350 nm were also obtained by using the standard spectrum of 12 mu g/mL QA. First derivative of the ratio spectra obtained in the above steps were calculated by Delta lambda=5 nm interval for both drugs. Calibration equation functions were obtained by measuring (he ratio spectra derivative amplitudes of the minima at 219.9 nm for QA and 283.2 nm for HCT in the above mentioned spectral ranges for each drug. In the numerical method, the critical wavelengths corresponding to maximum points at 213.0 nm for QA and 220.0 nm for HCT in the zero-order absorption spectra were selected to construct the least squares calibration (CLS). Both graphical and numerical methods developed in this study were completely validated and applied to the quantitative analysts of tablets containing QA and HCT The results obtained from the developed methods were compared with each other as well as to those obtained by classical derivative spectrophotometry, which have different experimental conditions than the previous derivative method, and the difference was not observed statistically significant.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Spectral Continuous Wavelet Transform for the Simultaneous Spectrophotometric Analysis of a Combined Pharmaceutical Formulation
    (Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
    Continuous wavelet transform (CWT) combined with zero crossing technique was proposed for the simultaneous spectrophotometric determination of telmisartan (TMS) and hydrochlorothiazide (HCT) in their binary mixtures without using a chemical pretreatment. This new hybrid analytical approach is based on the application of the CWT method to the absorption spectra of the analytes and their samples. In the signal analysis, Gaussian (GAUS3) with order 3 and BiorSplines (BIOR1.2) with 1.2 order were found to be suitable for the quantitative spectral resolution of TMS and HCT in samples. These hybrid approaches were named as GAUS3-CWT and BIOR1.2-CWT The validation of the CWT signal processing methods was carried out by using various binary mixtures of the analytes. The amounts of TMS and HCT in tablets were successfully determined by using the proposed GAUS3-CWT and BIOR1.2-CWT tools.
  • Article
    Citation - WoS: 6
    Citation - Scopus: 8
    Simple Mathematical Resolution for Binary Mixture of Oxfendazole and Oxyclozanide in Bolus by Bivariate and Multivariate Calibrations Based on the Linear Regression Functions
    (Editura Acad Romane, 2008) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Tokar, Ferdi; Matematik
    Two simple mathematical approaches were proposed for the simultaneous determination of oxfendazole (OXF) and oxyclozanide (OXY) in their synthetic binary mixtures and commercial veterinary formulation without requiring a priory separation step. One of these mathematical calibration techniques is called the bivariate calibration (BSC) based Oil four linear regression functions obtained at the wavelengths (230nm and 305 nm) with two single-component regression equations for each compound. The selection of the above mentioned wavelengths was performed by using the Kaiser technique. In the second mathematical approach, the multivariate spectral calibration (MSC) was constructed by a combined use of 42 linear regression functions consisting of 21 single linear regression equations for each compound at 21-wavelength set in between 230 and 330 run with intervals of Delta lambda=5nm. These two mathematical approaches were validated and applied to the quantitative analysis of the commercial veterinary formulation containing OXF and OXY. In this study successful results for the synthetic and real samples were reported.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 9
    Simultaneous Spectrophotometric Determination of Chlordiazepoxide and Clidinium Bromide in Sugar Coated Tablets by Partial Least Squares, Principal Component Regression and Artificial Neutral Network
    (Chiminform Data S A, 2006) Dinc, Erdal; Baleanu, Dumitru; Dermis, Saadet; Baleanu, Dumitru; Matematik
    Multivariate spectrophotometric approaches based on namely partial least squares (PLS), principal component regression (PCR) and artificial neural network (ANN) were proposed for the simultaneous determination of chlordiazepoxide (CHP) and clidinium bromide (CLB) in sugar coated tablets without any chemical separation step. As an alternative approach, ANN was applied to obtain the calibration function between the training data matrix and its corresponding absorbance data matrix. A training set consisting of 24 mixture solutions in the concentration range of 0-25 mu g/mL CHP and 0-30 mg/mL was prepared in methanol and 0.1 M NaOH (60:40, v/v). PLS and PCR calibrations were constructed by using their chemometric algorithms dependent on the relationships training set and absorbance data matrix obtained in the spectral range of 210-400 nm. As a comparison approach, ANN was applied to the determination of the investigated drugs in their mixtures and the commercial pharmaceutical preparation to clarify interactions between the analyzed compounds and excipients in samples. The validation of these chemometric methods was carried out by analyzing the artificial mixtures containing CHP and CLB drugs. The mathematical treatments were performed by using Microsoft Excel, a neural network algorithm written in Matlab 7.0 and the PLS toolbox 3.5. These multivariate approaches were successfully applied to the real CHP and CLB samples. As a result, the proposed chemometric methods were found suitable for the quality control and routine analysis of two drugs in sugar coated tablets.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 2
    Numerical and Graphical Approaches for the Simultaneous Quantitative Analysis of Levamizole and Oxyclozanide in Veterinary Formulation
    (Chiminform Data S A, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; Matematik
    Numerical (PLS and PCR calibrations) and graphical (second derivative spectrophotometry) methods were improved for the simultaneous quantitative analysis of levamizole (LEV) and oxyclozanide (OXC) in bolus. These methods do not require any priory separation for the analysis of the above drugs. In the case of numerical methods, a concentration set consisting of LEV and OXC in the concentration range of 0.0-25.0 mu g/mL was randomly prepared and the absorbances of the concentration set were measured at the wavelength set with Delta lambda = 0.1 nm in the spectral region of 210-260 nm. PCR and PLS calibrations were constructed by using the relationships between the concentration set and its corresponding absorbance data. In the case of the second derivative spectrophotometry (DS), the calibration functions for LEV and OXC in the range of 5.0-25.0 mu g/mL were obtained by measuring the second derivative amplitudes at 263.6 and 294 nm, respectively. All the proposed methods were validated by using the independent synthetic mixtures and standard addition technique. Then, these analytical methods applied to the commercial veterinary sample and results were compared with each other. A good coincidence was observed for the obtained experimental results.
  • Article
    Citation - WoS: 3
    Alternative Approaches To the Spectral Quantitative Resolution of Two-Component Mixture by Wavelet Families
    (Soc Chilena Quimica, 2009) Dinc, Erdal; Baleanu, Dumitru; Arslan, Fahrettin; Baleanu, Dumitru; Matematik
    A new spectral continuous wavelet transform (CWT) methods are proposed for the quantitative analysis of the binary mixtures. The simultaneous spectral resolution of binary mixtures and tablets containing paracetamol (PAR) and chloroxozone (CHL) with overlapping absorption spectra is performed by six wavelet families with no chemical separation procedure. The calibration graphs for the six wavelet families are obtained by the help of the data collected from the CWT-signal amplitudes corresponding to the zero crossing points in the spectral range of 210 nm-310 nm. The validation of each wavelet family is carried out by analyzing various synthetic binary mixtures of the above mentioned drugs. The second derivative spectrophotometry (D2) is used to compare the experimental results provided by the analyzed continuous wavelet families and a good coincidence is reported for the proposed analytical approaches.
  • Conference Object
    Continuous wavelet analysis for the ratio signals of the absorption spectra of binary mixtures
    (Springer, 2007) Dinç, Erdal; Baleanu, Dumitru; Taş, Kenan
    Wavelet analysis is successfully applied to the quantitative determination of the components in the binary mixture. This mathematical application is based on the use of the division of the absorption signals by the standard absorption signal and the transformation of the ratio signals. Calibration functions are obtained by measuring the continuous wavelet amplitudes corresponding to the minimum points of the wavelengths. The method is validated and applied to one example of binary mixture analysis.
  • Article
    Citation - Scopus: 11
    Wavelet Analysis for the Multicomponent Determination in a Binary Mixture of Caffeine and Propyphenazone in Tablets
    (Elsevier Masson SAS, 2004) Baleanu, D.; Aboul-Enein, H.Y.; Dinç, E.
    An approach based on both discrete and continuous wavelet analysis followed by a zero-crossing technique was developed. We applied this approach to obtain a high resolution in the binary mixture of caffeine (CA) and propyphenazone (PR) in the presence of their overlapping signals in the working length. The optimization of the wavelet families was accomplished for this mixture. The de-noise procedure was carried out by using 4-level Haar discrete wavelet transform and the resulted de-noised signal was investigated by continuous Mexican (MEX) and Haar (HA) transforms. Finally, a zero-crossing technique was applied on the transformed signal and the constructed calibration was tested by analyzing the composition of the different mixture containing CA and PR. All calculations have been performed within EXCEL and Matlab 6.5 software. The obtained results indicate that our procedure is flexible and applicable for the mixture analysis. © 2004 Elsevier SAS. All rights reserved.