Matematik Bölümü Yayın Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/413
Browse
10 results
Search Results
Article Citation - WoS: 1Citation - Scopus: 4Fractional Modeling of Cancer With Mixed Therapies(Imr Press, 2023) Ul Abdeen, Zain; Baleanu, Dumitru; Javeed, ShumailaBackground: Cancer is the biggest cause of mortality globally, with approximately 10 million fatalities expected by 2020, or about one in every six deaths. Breast, lung, colon, rectum, and prostate cancers are the most prevalent types of cancer. Methods: In this work, fractional modeling is presented which describes the dynamics of cancer treatment with mixed therapies (immunotherapy and chemotherapy). Mathematical models of cancer treatment are important to understand the dynamical behavior of the disease. Fractional models are studied considering immunotherapy and chemotherapy to control cancer growth at the level of cell populations. The models consist of the system of fractional differential equations (FDEs). Fractional term is defined by Caputo fractional derivative. The models are solved numerically by using Adams-Bashforth-Moulton method. Results: For all fractional models the reasonable range of fractional order is between beta = 0.6 and beta = 0.9. The equilibrium points and stability analysis are presented. Moreover, positivity and boundedness of the solution are proved. Furthermore, a graphical representation of cancerous cells, immunotherapy and chemotherapy is presented to understand the behaviour of cancer treatment. Conclusions: At the end, a curve fitting procedure is presented which may help medical practitioners to treat cancer patients.Article Citation - WoS: 86Qualitative Analysis of a Mathematical Model in the Time of Covid-19(Hindawi Ltd, 2020) Mahariq, Ibrahim; Jarad, Fahd; Shah, Kamal; Abdeljawad, ThabetIn this article, a qualitative analysis of the mathematical model of novel corona virus named COVID-19 under nonsingular derivative of fractional order is considered. The concerned model is composed of two compartments, namely, healthy and infected. Under the new nonsingular derivative, we, first of all, establish some sufficient conditions for existence and uniqueness of solution to the model under consideration. Because of the dynamics of the phenomenon when described by a mathematical model, its existence must be guaranteed. Therefore, via using the classical fixed point theory, we establish the required results. Also, we present the results of stability of Ulam's type by using the tools of nonlinear analysis. For the semianalytical results, we extend the usual Laplace transform coupled with Adomian decomposition method to obtain the approximate solutions for the corresponding compartments of the considered model. Finally, in order to support our study, graphical interpretations are provided to illustrate the results by using some numerical values for the corresponding parameters of the model.Article Citation - WoS: 15Citation - Scopus: 18A Mathematical and Statistical Estimation of Potential Transmission and Severity of Covid-19: A Combined Study of Romania and Pakistan(Hindawi Ltd, 2020) Hussain, Takasar; Hussain, Mureed; Awan, Aziz Ullah; Baleanu, Dumitru; Abro, Kashif Ali; Ozair, MuhammadDuring the outbreak of an epidemic, it is of immense interest to monitor the effects of containment measures and forecast of outbreak including epidemic peak. To confront the epidemic, a simple SIR model is used to simulate the number of affected patients of coronavirus disease in Romania and Pakistan. The model captures the growth in case onsets, and the estimated results are almost compatible with the actual reported cases. Through the calibration of parameters, forecast for the appearance of new cases in Romania and Pakistan is reported till the end of this year by analysing the current situation. The constant level of number of patients and time to reach this level is also reported through the simulations. The drastic condition is also discussed which may occur if all the preventive restraints are removed.Article Citation - WoS: 28Citation - Scopus: 27Competitive Numerical Analysis for Stochastic Hiv/Aids Epidemic Model in a Two-Sex Population(inst Engineering Technology-iet, 2019) Rafiq, Muhammad; Baleanu, Dumitru; Shoaib Arif, Muhammad; Naveed, Muhammad; Ashraf, Kaleem; Raza, Ali; Arif, Muhammad ShoaibThis study is an attempt to explain a reliable numerical analysis of a stochastic HIV/AIDS model in a two-sex population considering counselling and antiretroviral therapy (ART). The authors are comparing the solutions of the stochastic and deterministic HIV/AIDS epidemic model. Here, an endeavour has been made to explain the stochastic HIV/AIDS epidemic model is comparatively more pragmatic in contrast with the deterministic HIV/AIDS epidemic model. The effect of threshold number H* holds on the stochastic HIV/AIDS epidemic model. If H* < 1 then condition helps us to control disease in a two-sex human population while H* > 1 explains the persistence of disease in the two-sex human population. Lamentably, numerical methods such as Euler-Maruyama, stochastic Euler, and stochastic Runge-Kutta do not work for large time step sizes. The recommended structure preserving framework of the stochastic non-standard finite difference (SNSFD) scheme conserve all vital characteristics such as positivity, boundedness, and dynamical consistency defined by Mickens. The effectiveness of counselling and ART may control HIV/AIDS in a two-sex population.Article Citation - WoS: 17Citation - Scopus: 19Competitive Analysis for Stochastic Influenza Model With Constant Vaccination Strategy(inst Engineering Technology-iet, 2019) Raza, Ali; Rafiq, Muhammad; Arif, Muhammad Shoaib; Ali, Muhammad Asghar; Baleanu, DumitruThis manuscript discusses a competitive analysis of stochastic influenza model with constant vaccination strategy. The stochastic influenza model is comparatively more pragmatic versus the deterministic influenza model. The effect of influenza generation number holds in the stochastic model. If the value of this number is less than one, this situation will help us to control the disease in a population. A greater than one value of this threshold number shows the persistence of disease to become endemic. The proposed structure for the stochastic influenza model as stochastic non-standard finite difference scheme conserve all vital characteristics like positivity, boundedness and dynamical consistency defined by Mickens.Article Citation - WoS: 19Citation - Scopus: 25Analysis for Fractional-Order Predator-Prey Model With Uncertainty(inst Engineering Technology-iet, 2019) Baleanu, Dumitru; Thangapandi, Kalidas; Perera, Shyam Sanjeewa Nishantha; Narayanamoorthy, SamayanHere, the authors analyse the fractional-order predator-prey model with uncertainty, due to the vast applications in various ecological systems. The most of the ecological model do not have exact analytic solution, so they proposed a numerical technique for an approximate solution. In the proposed method, they have implemented the higher order term into the fractional Euler method to enhance the precise solution. Further, the present attempt is aimed to discuss the solutions of the FPPM with uncertainty (fuzzy) initial conditions. The initial conditions of the predator-prey model were taken as fuzzy initial conditions due to the fact that the ecological model highly depends on uncertain parameters such as growth/decay rate, climatic conditions, and chemical reactions. Finally, the numerical example manifest that the proposed method is authentic, applicable, easy to use from a computational viewpoint and the acquired outcomes are balanced with the existing method (HPM), which shows the efficiency of the proposed method.Article Citation - WoS: 6Citation - Scopus: 7Fractional-Continuous Wavelet Transforms and Ultra-Performance Liquid Chromatography for the Multicomponent Analysis of a Ternary Mixture Containing Thiamine, Pyridoxine, and Lidocaine in Ampules(Oxford Univ Press inc, 2012) Baleanu, Dumitru; Dinc, ErdalNew chemometric approaches based on the application of partial least squares (PLS) and principal component regression (PCR) algorithms with fractional wavelet transform (FWT) and continuous wavelet transform (CWT) are proposed for the spectrophotometric multicomponent determination of thiamine hydrochloride (B-1), pyridoxine hydrochloride (B-6), and lidocaine hydrochloride (LID) in ampules without any separation step. In this study PLS and PCR techniques were applied to the raw spectral data, FWT-coefficients, and FWT-CWT-coefficients. These calibration models were labeled as Raw-PLS and Raw-PCR, FWT-PLS and FWT-PCR, and FWT-CWT-PLS and FWT-CWT-PCR, respectively. A new ultra-performance liquid chromatographic (UPLC) method was developed for the comparison of the results obtained by applying the chemometric calibration methods. Chromatographic separation and determination of B-1, B-6, and LID in ampules were performed on an Acquity UPLC (R) BEH C18 column (50 x 2.1 mm id, 1.7 mu m particle size) using gradient elution with a mobile phase consisting of methanol and 0.01 M HCl at a constant flow rate of 0.6 mL/min. These combined chemometric calibrations and UPLC were validated by analyzing various ternary mixtures, B-1, B-6, and LID. The proposed chemometric approaches (signal processing-multivariate calibrations) and UPLC method were applied to the quantitative multicomponent analysis of marketed ampules containing the vitamins B1 and B-6 with LID.Article Citation - WoS: 36Adaptive Fractional-Order Blood Glucose Regulator Based on High-Order Sliding Mode Observer(inst Engineering Technology-iet, 2019) Heydarinejad, Hamid; Baleanu, Dumitru; Delavari, HadiType I diabetes is described by the destruction of the insulin-producing beta-cells in the pancreas. Hence, exogenous insulin administration is necessary for Type I diabetes patients. In this study, to estimate the states that are not directly available from the Bergman minimal model a high-order sliding mode observer is proposed. Then fractional calculus is combined with sliding mode control (SMC) for blood glucose regulation to create more robustness performance and make more degree of freedom and flexibility for the proposed method. Then an adaptive fractional-order SMC is proposed. The adaptive SMC protect controller against disturbance and uncertainties while the fractional calculus provides robust performance. Numerical simulation verifies that the proposed controllers have better performance in the presence of disturbance and uncertainties without chattering.Article Citation - WoS: 58Citation - Scopus: 60Scintillation Index of Modified Bessel-Gaussian Beams Propagating in Turbulent Media(Optical Soc Amer, 2009) Baykal, Yahya; Sermutlu, Emre; Korotkova, Olga; Cai, Yangjian; Eyyuboglu, Halil T.The scintillation index is formulated for modified Bessel-Gaussian beams propagating in weakly turbulent media. Numerical calculations applied directly to the derived triple integral show that, for off-axis positions, the modified Bessel-Gaussian beams of higher than zero order scintillate less than Gaussian beams at large input beam sizes and low beam orders with the increasing width parameter initially contributing positively to this phenomenon of less scintillation. As the beam order exceeds two, this advantage is diminished. The modified Bessel-Gaussian beam of order zero is a special case, however, exhibiting lowest scintillation at small input beam sizes. When considered against the propagation length, higher-order modified Bessel-Gaussian beams continue to offer less scintillation than those of order zero. At various radial positions, the scintillation index of modified Bessel-Gaussian beams with orders higher than zero attains small values toward the beam edges but rises sharply when approaching the beam axis. The effect of inner and outer scales of turbulence is also studied, and it is found that while increasing the inner scale of turbulence seems to cause increases in scintillation, the influence of the outer scale is hardly noticeable. (C) 2009 Optical Society of AmericaArticle Citation - WoS: 31Citation - Scopus: 40Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by Hplc(Pharmaceutical Soc Japan, 2006) Özdemir, A; Aksoy, H; Üstündag, Ö; Baleanu, D; Dinç, E; Baleanud, DumitruA new chemometric determination by high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was implemented for the simultaneous determination of naproxen sodium and pseudoephedrine hydrochloride in tablets. Three chemometric calibration techniques, classical least squares (CLS), principle component regression (PCR) and partial least squares (PLS) were applied to the peak area at multiwavelength PDA detector responses. The combinations of HPLC with chernometric calibration techniques were called HPLC-CLS, HPLC-PCR and HPLC-PLS. For comparison purposes the HPLC method called the classic HPLC method was used to confirm the results obtained from combined HPLC-chemometric calibration techniques. A good chromatographic separation between two drugs with losartan potassium as an internal standard was achieved using a Waters Symmetry (R) C18 Column 5 mu m 4.6 +/- 250 mm and a mobile phase containing 0.2 m acetate buffer and acetonitrile (v/v, 40 : 60). The multiwavelength PDA detection was measured at five different wavelengths. The chromatograms were recorded as a training set in the mobile phase. Three HPLC-chemometric calibrations and the classic-HPLC method were used to test the synthetic mixtures of naproxen sodium and pseudoephedrine hydrochloride in the presence of the internal standard. The HPLC-chemometric approaches were applied to real samples containing drugs of interest. The experimental results obtained from HPLC-chemometric calibrations were compared with those obtained by a classic HPLC method.