WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8653
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Article Citation - WoS: 22Citation - Scopus: 28Simultaneous Determination of Tartrazine and Allura Red in Commercial Preparation by Chemometric Hplc Method(Food & Drug Adminstration, 2006) Dinc, Erdal; Baleanu, Dumitru; Aktas, A. Hakan; Baleanu, Dumitru; Ustundag, Ozgur; MatematikThe concentrations of tartrazine (TAR) and allura red (ALL) in binary mixtures and commercial preparation were determined by the combined use of chemometric (or multivariate) calibrations and HPLC method. In this study, partial least squares (PLS), principal component regression (PCR) and classical least squares (CLS) based on multiwavelength HPLC data were refined as multivariate calibration techniques such as CPLS, CPCR, CCLS. The relation between multiwavelength peak area data (x-block) and concentration set (y-block) were used to obtain the chromatographic multivariate calibrations. Multiwavelength-chromatograms or multiwavelength peak area data were obtained by using photodiode array (PDA) detectors. Waters Symmetry (R) C18 Column 5 mu m 4.6 x 250 mm and a combination of 0.2 M acetate buffer (pH = 5), acetonitrile, methanol and bidistilled water (55:20:10 v/v) at the flow rate of 1.9 mL/min were used to obtain a good chromatographic separation between TAR and ALL in presence of sunset yellow (Internal Standard (IS)). These chromatographic multivariate techniques were validated by analyzing the different synthetic mixtures and by using standard addition technique. These methods were applied to the commercial soft drinking powder samples containing TAR and ALL. The results from these chromatographic multivariate techniques were compared with each other as well as obtained by alternative single HPLC method.Article Citation - WoS: 14Citation - Scopus: 23Continuous Wavelet Transform Applied To the Overlapping Absorption Signals and Their Ratio Signals for the Quantitative Resolution of Mixture of Oxfendazole and Oxyclozanide in Bolus(Food & Drug Adminstration, 2007) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikContinuous wavelet transform (CWT) was applied to the overlapping absorption signals and their ratio signals for the quantitative resolution of mixture of oxfendazole (OXF) and oxyclozanide (OXY) in bolus without using any pre-chemical treatment. Mexican hat function (MEXH) and Morlet (MORL) continuous wavelet transforms (MEXH-CWT and MORL-CWT) for signal treatments were found to be suitable among the wavelet families. In the first step MEXH-CWT together with zero crossing technique is directly applied to the overlapping absorption spectra of OXF and OXY drugs and their calibration graphs were obtained by measuring the MEXH-CWT amplitudes at 328.7 nm for OXY and at 309.3 nm for OXF in the wavelet domain of 255-365 nm. In the second step MORL-CWT is used for finding the significant peak resolution of the ratio spectra of OXY and OXF respectively. The maxima and minima of CWT amplitudes and peak-to-peak and zero-crossing techniques were used for the calibration graphs. The method performances of CWT-zero crossing and ratio spectra-CWT techniques were validated by analyzing the synthetic mixtures and by applying the standard addition technique, and successfully accuracy, precision and reproducibility results were reported.