WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8653
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Article Citation - WoS: 3Citation - Scopus: 2Chemometric Simultaneous Determination of Atorvastatin and Amlodipine in Tablets by Pcr and Pls Calibrations(Chiminform Data S A, 2009) Dinc, Erdal; Baleanu, Dumitru; Baleanu, Dumitru; MatematikPrincipal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of atorvastatin (ATO) and amlodipine (AML) in tablets without using a preliminary separation and even in presence of the overlapping spectra of the above mentioned compounds. For both PCR and PLS methods, a concentration set containing 17 different mixtures of ATO and AML in the linear concentration range of 0.0-20.0 mg/mL for both compounds was randomly prepared and then the absorbance values of the concentration set were measured at the 551 points-wavelength set with interval of Delta lambda=0.1 nm from 215 nm to 2 70 nm in the spectral range of 202320 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. These analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.Article Citation - WoS: 4Citation - Scopus: 4Fractional Wavelet Transform for the Quantitative Spectral Resolution of the Commercial Veterinary Preparations(Chiminform Data S A, 2011) Kambur, Murat; Baleanu, Dumitru; Narin, Ibrahim; Dinc, Erdal; Candir, Secil; Baleanu, Dumitru; MatematikFractional wavelet transform was applied to the quantitative spectral analysis of oxytetracycline and flunixin megluminein in a veterinary combination. A concentration set of 15 binary mixtures containing oxytetracycline and flunixin megluminein in the range of 4-36 mu g/mL oxytetracycline and 2-34 mu g/mL flunixin megluminein were processed by fractional wavelet transform (FWT) method. Partial least squares (PLS) and principal component regression (PCR) were applied to the FWT-coefficients to obtain FWT-PCR and FWT-PLS. The validity of the proposed FWT-PLS and FWT-PCR approaches were carried out by analyzing the synthetic binary mixtures of the related veterinary compounds. The proposed combined approaches were used for the quality control of the commercial veterinary formulation of compounds.Article Citation - WoS: 7Citation - Scopus: 9Simultaneous Spectrophotometric Determination of Chlordiazepoxide and Clidinium Bromide in Sugar Coated Tablets by Partial Least Squares, Principal Component Regression and Artificial Neutral Network(Chiminform Data S A, 2006) Dinc, Erdal; Baleanu, Dumitru; Dermis, Saadet; Baleanu, Dumitru; MatematikMultivariate spectrophotometric approaches based on namely partial least squares (PLS), principal component regression (PCR) and artificial neural network (ANN) were proposed for the simultaneous determination of chlordiazepoxide (CHP) and clidinium bromide (CLB) in sugar coated tablets without any chemical separation step. As an alternative approach, ANN was applied to obtain the calibration function between the training data matrix and its corresponding absorbance data matrix. A training set consisting of 24 mixture solutions in the concentration range of 0-25 mu g/mL CHP and 0-30 mg/mL was prepared in methanol and 0.1 M NaOH (60:40, v/v). PLS and PCR calibrations were constructed by using their chemometric algorithms dependent on the relationships training set and absorbance data matrix obtained in the spectral range of 210-400 nm. As a comparison approach, ANN was applied to the determination of the investigated drugs in their mixtures and the commercial pharmaceutical preparation to clarify interactions between the analyzed compounds and excipients in samples. The validation of these chemometric methods was carried out by analyzing the artificial mixtures containing CHP and CLB drugs. The mathematical treatments were performed by using Microsoft Excel, a neural network algorithm written in Matlab 7.0 and the PLS toolbox 3.5. These multivariate approaches were successfully applied to the real CHP and CLB samples. As a result, the proposed chemometric methods were found suitable for the quality control and routine analysis of two drugs in sugar coated tablets.Article Citation - WoS: 7Citation - Scopus: 10Simultaneous Chemometric Determination of Pyridoxine Hydrochloride and Isoniazid in Tablets by Multivariate Regression Methods(Wiley-blackwell, 2010) Ustundag, Ozgur; Baleanu, Dumitru; Dinc, ErdalThe sole use of pyridoxine hydrochloride during treatment of tuberculosis gives rise to pyridoxine deficiency. Therefore, a combination of pyridoxine hydrochloride and isoniazid is used in pharmaceutical dosage form in tuberculosis treatment to reduce this side effect. In this study, two chemometric methods, partial least squares (PLS) and principal component regression (PCR), were applied to the simultaneous determination of pyridoxine (PYR) and isoniazid (ISO) in their tablets. A concentration training set comprising binary mixtures of PYR and ISO consisting of 20 different combinations were randomly prepared in 0.1 M HCl. Both multivariate calibration models were constructed using the relationships between the concentration data set (concentration data matrix) and absorbance data matrix in the spectral region 200-330 nm. The accuracy and the precision of the proposed chemometric methods were validated by analyzing synthetic mixtures containing the investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to the artificial mixtures were found between 100.0 and 100.7%. Satisfactory results obtained by applying the PLS and PCR methods to both artificial and commercial samples were obtained. The results obtained in this manuscript strongly encourage us to use them for the quality control and the routine analysis of the marketing tablets containing PYR and ISO drugs. Copyright (C) 2010 John Wiley & Sons, Ltd.Article Citation - WoS: 21Citation - Scopus: 23New Approach for Simultaneous Spectral Analysis of a Complex Mixture Using the Fractional Wavelet Transform(Elsevier, 2010) Demirkaya, Fatma; Baleanu, Dumitru; Kadioglu, Yuecel; Kadioglu, Ekrem; Dinc, ErdalFractional wavelet transform (FWT) is a powerful toot in order to extract largest analytical information from the spectral bands. For the above reason, the combined applications of fractional wavelet transform with principal component regression (PCR) and partial least squares (PLS) calibrations are performed for the quantitative analysis of a pharmaceutical mixture containing trimethoprim (TMP) and sulphamethoxazole (SMX). One interesting example of complex pharmaceutical mixture is given by the multi-component pharmaceutical sample having constant matrix content. In this study, the absorption spectra of the related compounds and their samples were processed by fractional wavelet transform. In the following procedure, FWT-coefficients obtained in the above step are used to construct the PCR and PLS calibrations. These hybrid mathematical approaches are denoted as FWT-PCR and FWT-PLS calibrations. FWT-PCR and FWT-PLS obtained by using the FWT-coefficients for the quantitative analysis of TMP and SMX gives the higher accurate and precise results than classical PCR and PLS based on the use of the original absorbance values. (C) 2009 Elsevier B.V. All rights reserved.Article Citation - WoS: 9Citation - Scopus: 10Spectrophotometric Simultaneous Determination of Levamisole and Triclabendazole in Tablets by Principal Component Regrassion and Partial Least Squares Chemometric Methods(Chiminform Data S A, 2008) Dinc, Erdal; Baleanu, Dumitru; Pektas, GozdePrincipal component regression (PCR) and partial least squares (PLS) chemometric methods were applied to the simultaneous quantitative analysis of levamisole (LVM) and triclabendazole (TCB) in tablets without using a preliminary separation, even in presence of the overlapping spectra of the above compounds. For both PCR and PLS, a concentration set containing 25 different mixtures of LVM and TCB in the linear concentration range was symmetrically prepared and then the absorbance values of the concentration set were measured at the wavelength set with Delta lambda=0. 1nm in the spectral region of 225-322.3 nm. PCR and PLS calibrations were obtained by applying the PCR and PLS algorithms to the concentration set data (y-block) and their corresponding absorbance data (x-block). The validity of PCR and PLS chemometric methods was performed by using the independent synthetic mixtures and the standard addition technique. Then, these analytical methods were applied to the commercial tablets and a good agreement was obtained between experimental results provided by the application of the PCR and PLS to the synthetic and real samples.