PubMed İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12416/8650
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Article Beam Shaping on a Fluorescent On-Chip Imaging System(IOP Publishing Ltd, 2026) Arpali, Caglar; Arpali, Serap AltayThe fluorescent on-chip imaging system differs from a conventional fluorescent microscope in terms of the imaging method because the sample is directly placed on the imaging sensor (i.e., charge-coupled device (CCD)). While this imaging modality presents several advantages, including a wide field of view and rapid scanning speed, it can be difficult to detect certain particles in dense and scattering environments, such as whole blood and tissue. These difficulties lead to a decreased signal-to-noise ratio (SNR) in the captured images, influenced by both the medium's light-transmitting capability and the excitation techniques used. In this paper, we quantitatively examine the effect of beam shaping techniques on a fluorescent on-chip imaging system from the SNR perspective. An experimental comparison is conducted between a Gaussian beam and plane-wave illumination generated by a novel phase modulation schema using our developed imaging platform. The results indicate that the Gaussian beam produces higher SNR images than plane waves when detecting fluorescent particles in a microchannel. Gaussian beam's higher energy confinement ability enhances the image quality of on-chip fluorescent imaging systems, particularly involving scattering-like medium limitations.Article Developing and Validating a Rubric-Based Approach to Quality Assurance in Turkish Higher Education(Pergamon-Elsevier Science Ltd, 2025) Akkoyunlu, Buket; Bardakci, Salih; Yildirim, Sibel Aksu; Avsaroglu, M. Dilek; Uludag, Gonca; Kocer, Ayhan; Elmas, MuzafferThis study, initiated by the Turkish Higher Education Quality Council (THEQC), develops and validates a rubricbased approach for evaluating institutional quality assurance (QA) processes within the Turkish higher education ecosystem. Effective quality assurance (QA) in higher education requires evaluation tools that are methodologically robust, responsive to institutional needs, and aligned with international benchmarks. A rubric-based approach offers a structured and transparent framework for consistent assessments. The rubric was created through an iterative, evidence-based process incorporating expert feedback, international benchmarks, site visits, and prior research. It consists of 22 main criteria across four key domains-Leadership, Governance and Quality; Learning and Teaching; Research and Development; and Service to Society-subdivided into 46 sub-criteria, each assessed on a five-point maturity scale. The validity and reliability of the rubric were rigorously examined. Content validity was established through evaluations by 10 QA professionals, addressing four key dimensions: relevance, alignment with the intended domain, appropriateness for the target audience, and clarity of language. Construct and criterion validity were assessed through consistency checks and usability analyses, with data collected from 252 external evaluators across 57 higher education institutions. Additionally, 360-degree feedback was gathered from both external evaluation teams and the institutions involved in the evaluation process. Results: demonstrate strong content validity (Lawshe coefficient =1.00, p < .05), high interrater consistency, and strong usability across various evaluator groups. Further evaluation confirmed the rubric's applicability and robustness across diverse institutional contexts. This study concludes that the developed rubric is a reliable and valid tool for enhancing and evaluating quality assurance practices in higher education.Article Citation - WoS: 3Citation - Scopus: 2Evaluation of the Effects of Avatar on Learning Temporomandibular Joint in a Metaverse-Based Training(John Wiley and Sons Inc, 2024) Basmaci, Fulya; Bulut, Ali Can; Ozcelik, Erol; Ekici, Saliha Zerdali; Kilicarslan, Mehmet Ali; Cagiltay, Nergiz Ercil; Zerdali Ekici, SalihaPurposeAvatars, representing users in the digital world, can influence users' behavior and attitudes. This study evaluates the impact of representing dental students receiving temporomandibular joint (TMJ) education in the metaverse via an anonymous or identified avatar.MethodsParticipants included 80 dental students in their fourth and fifth years of study. They were randomly assigned to either the avatar group (identified avatar) or the control group (anonymous avatar). Prior to training, participants completed a demographic questionnaire and a pretraining knowledge assessment. TMJ training was conducted in the metaverse for both groups. Pre- and post-training assessments included the Spielberger State-Trait Anxiety Inventory and a shyness scale to ensure group comparability. A post-test consisting of five questions was administered to both groups after 2 weeks of training.ResultsThere were no significant differences in pretraining scores for prior knowledge (p = 0.67), trait anxiety (p = 0.28), state anxiety (p = 0.92), or shyness (p = 0.42) between the avatar and control groups, indicating comparability at baseline. Post-training analysis revealed significantly higher post-test scores in the avatar group (median = 80) compared to the control group (median = 60) (p = 0.03).ConclusionsMetaverse environments offer various benefits for students, educators, and educational institutions in health education programs. Representing learners and their identities in training environments can enhance learning outcomes.Article Citation - WoS: 3Citation - Scopus: 3Expectancy From, and Acceptance of Augmented Reality in Dental Education Programs: a Structural Equation Model(Wiley, 2024) Toker, Sacip; Akay, Canan; Basmaci, Fulya; Kilicarslan, Mehmet Ali; Mumcu, Emre; Cagiltay, Nergiz ErcilObjectiveDental schools need hands-on training and feedback. Augmented reality (AR) and virtual reality (VR) technologies enable remote work and training. Education programs only partially integrated these technologies. For better technology integration, infrastructure readiness, prior-knowledge readiness, expectations, and learner attitudes toward AR and VR technologies must be understood together. Thus, this study creates a structural equation model to understand how these factors affect dental students' technology use.MethodsA correlational survey was done. Four questionnaires were sent to 755 dental students from three schools. These participants were convenience-sampled. Surveys were developed using validity tests like explanatory and confirmatory factor analyses, Cronbach's alpha, and composite reliability. Ten primary research hypotheses are tested with path analysis.ResultsA total of 81.22% responded to the survey (755 out of 930). Positive AR attitude, expectancy, and acceptance were endogenous variables. Positive attitudes toward AR were significantly influenced by two exogenous variables: infrastructure readiness (B = 0.359, beta = 0.386, L = 0.305, U = 0.457, p = 0.002) and prior-knowledge readiness (B = -0.056, beta = 0.306, L = 0.305, U = 0.457, p = 0.002). Expectancy from AR was affected by infrastructure, prior knowledge, and positive and negative AR attitudes. Infrastructure, prior-knowledge readiness, and positive attitude toward AR had positive effects on expectancy from AR (B = 0.201, beta = 0.204, L = 0.140, U = 0.267, p = 0.002). Negative attitude had a negative impact (B = -0.056, beta = -0.054, L = 0.091, U = 0.182, p = 0.002). Another exogenous variable was AR acceptance, which was affected by infrastructure, prior-knowledge preparation, positive attitudes, and expectancy. Significant differences were found in infrastructure, prior-knowledge readiness, positive attitude toward AR, and expectancy from AR (B = 0.041, beta = 0.046, L = 0.026, U = 0.086, p = 0.054).ConclusionInfrastructure and prior-knowledge readiness for AR significantly affect positive AR attitudes. Together, these three criteria boost AR's potential. Infrastructure readiness, prior-knowledge readiness, positive attitudes toward AR, and AR expectations all increase AR adoption. The study provides insights that can help instructional system designers, developers, dental education institutions, and program developers better integrate these technologies into dental education programs. Integration can improve dental students' hands-on experience and program performance by providing training options anywhere and anytime.Article Citation - WoS: 3Citation - Scopus: 4Your Need for Cognition, Cognitive Flexibility, and Cognitive Emotion Regulation Strategies Matter! the Path Beyond a Satisfied Life(Routledge Journals, Taylor & Francis Ltd, 2024) Kaynak, Hande; Nazligul, Merve Denizci; Cengil, Betul Beyza; Denizci Nazlıgül, MerveThis study explored the associations among cognitive flexibility, cognitive emotion regulation (CER) strategies, need for cognition, and life satisfaction, which represents a cognitive component of subjective well-being. Previous studies have shown the importance of adaptive CER strategies for well-being, while maladaptive strategies have been linked to negative outcomes such as psychological distress, depression, and anxiety. Additionally, the need for cognition has been associated with cognitive flexibility and positive outcomes in various domains. However, the specific roles of cognitive flexibility and CER strategies in the relationship between need for cognition and life satisfaction remain relatively unexplored in the existing literature. This study aimed to address this gap by investigating how cognitive flexibility and different CER strategies contribute to the relationship between need for cognition and life satisfaction in a non-clinical sample of 239 adults via a survey consisting of a demographic information form, need for cognition scale, cognitive flexibility inventory, cognitive emotion regulation questionnaire, and satisfaction with life scale. The results demonstrated that when individuals with a high need for cognition had cognitive flexibility, they were more likely to use adaptive cognitive emotion regulation strategies, resulting in elevated life satisfaction. The findings of this study may provide insights into the underlying mechanisms that influence individuals' cognitive processes, cognitive emotional regulation, and overall life satisfaction. Such understanding can have implications for interventions aimed at enhancing cognitive flexibility, promoting adaptive CER strategies, and ultimately fostering improved life satisfaction.Article Citation - WoS: 5Paulus Aegineta Review of Spine-Related Chapters in "epitomoe Medicoe Libri Septem(Lippincott Williams & Wilkins, 2013) Er, Uygur; Naderi, SaitStudy Design. Analysis of chapters related to spinal fractures and dislocations of an important medical book from medieval age. A historical study. Objective. To present the sections on spinal fractures and dislocations in the treatise of Paulus Aegineta or Paul of Aegina, and to discuss their relationship with preceding and subsequent literature. Summary of Background Data. Paul of Aegina was influenced by precedent great authors and provided a significant link in the transmission of the surgical knowledge to present day via the prominent physicians of Islamic golden age. Methods. The edition on which this study is based was translated from Greek into English by Francis Adams and was published in 1846 by The Sydenham Society in London in 3 volumes. The related sections were examined and compared with the treatises of earlier and subsequent writers. Results. Although Paul of Aegina was influenced by Hippocrates, Celsus, and Galen, he also put forward his own opinions. The most prominent representatives of the Islamic Golden Age, Rhazes, Albucasis, Avicenna, and Haly Abas were influenced by Paul of Aegina. Conclusion. Paul of Aegina, who was the last representative of the Byzantine School, compiled approximately 1000 years of medical knowledge up to his own era. By taking on this task, he provided a significant link in the transmission of ancient knowledge to later generations. He is also considered as a bridge between Western and Eastern medicines as he conveyed medical knowledge of the ancient era to Islamic authors.Article Citation - WoS: 3Citation - Scopus: 5Incivility, Mobbing, and Abusive Supervision: a Tripartite Scale Development Study(Routledge Journals, Taylor & Francis Ltd, 2024) Sumer, H. Canan; Goncu-Kose, Asli; Toker-Gultas, Yonca; Acar, F. Pinar; Karanfil, Derya; Ok, A. BasakUsing qualitative and quantitative methodologies, in three consecutive studies with employed samples, we developed measures of workplace incivility, mobbing, and abusive supervision sensitive to the nuances of a non-Western context (i.e., Turkiye). In Study 1, we first conducted 15 focus groups (N = 149), identified culture-specific and universal themes underlying the focal mistreatment types, and developed the initial scales. We then pilot-tested (N = 427) and refined the scales using exploratory factor analytic procedures. In Study 2, confirmatory factor analyses (N range = 456-524) and associations between the new scales and their widely used counterparts (N = 353) yielded evidence for the construct validity of the scales. Study 2 also involved the development of short forms of relatively long incivility and abusive supervision scales. In Study 3 (N = 482), we first examined the extent to which the three scales were operationally distinct. Second, we examined the scales' ability to predict burnout and organizational commitment. Results supported operational distinctiveness as well as the criterion-related validity of the scales. A dominance analysis revealed that the three scales had equivalent contributions in explaining the two outcome variables, further justifying their distinctiveness. We argue that the use of present scales is not necessarily restricted to the Turkish context and may prove useful more broadly in other neo-traditional contexts.Article -Simultaneous chemometric determination of pyridoxine hydrochloride and isoniazid in tablets bymultivariate regression methods(Wiley-Blackwell, 2010) Dinç, Erdal; Üstündağ, Ögür; Baleanu, DumitruThe sole use of pyridoxine hydrochloride during treatment of tuberculosis gives rise to pyridoxine deficiency. Therefore, a combination of pyridoxine hydrochloride and isoniazid is used in pharmaceutical dosage form in tuberculosis treatment to reduce this side effect. In this study, two chemometric methods, partial least squares (PLS) and principal component regression (PCR), were applied to the simultaneous determination of pyridoxine (PYR) and isoniazid (ISO) in their tablets. A concentration training set comprising binary mixtures of PYR and ISO consisting of 20 different combinations were randomly prepared in 0.1 M HCl. Both multivariate calibration models were constructed using the relationships between the concentration data set (concentration data matrix) and absorbance data matrix in the spectral region 200-330 nm. The accuracy and the precision of the proposed chemometric methods were validated by analyzing synthetic mixtures containing the investigated drugs. The recovery results obtained by applying PCR and PLS calibrations to the artificial mixtures were found between 100.0 and 100.7%. Satisfactory results obtained by applying the PLS and PCR methods to both artificial and commercial samples were obtained. The results obtained in this manuscript strongly encourage us to use them for the quality control and the routine analysis of the marketing tablets containing PYR and ISO drugs. CopyrightArticle Citation - WoS: 2Existence of Measure Pseudo-Almost Automorphic Functions and Applications To Impulsive Integro-Differential Equation(Aip Publishing, 2021) Baleanu, Dumitru; George, Soumya; Grayna, J.; Kavitha, V.This article's main objective is to establish the measure pseudo-almost automorphic solution of an integro-differential equation with impulses. We develop the existence results based on the Banach contraction principle mapping and Krasnoselskii and Krasnoselskii-Schaefer type fixed point theorems. Finally, some examples are given to illustrate the significance of our theoretical findings.Published under an exclusive license by AIP PublishingArticle Citation - WoS: 43Citation - Scopus: 50Detection of Hip Osteoarthritis by Using Plain Pelvic Radiographs With Deep Learning Methods(Springer, 2020) Ureten, Kemal; Arslan, Tayfun; Gultekin, Korcan Emre; Demir, Ayse Nur Demirgoz; Ozer, Hafsa Feyza; Bilgili, YaseminObjective The incidence of osteoarthritis is gradually increasing in public due to aging and increase in obesity. Various imaging methods are used in the diagnosis of hip osteoarthritis, and plain pelvic radiography is the first preferred imaging method in the diagnosis of hip osteoarthritis. In this study, we aimed to develop a computer-aided diagnosis method that will help physicians for the diagnosis of hip osteoarthritis by interpreting plain pelvic radiographs. Materials and methods In this retrospective study, convolutional neural networks were used and transfer learning was applied with the pre-trained VGG-16 network. Our dataset consisted of 221 normal hip radiographs and 213 hip radiographs with osteoarthritis. In this study, the training of the network was performed using a total of 426 hip osteoarthritis images and a total of 442 normal pelvic images obtained by flipping the raw data set. Results Training results were evaluated with performance metrics such as accuracy, sensitivity, specificity, and precision calculated by using the confusion matrix. We achieved accuracy, sensitivity, specificity and precision results at 90.2%, 97.6%, 83.0%, and 84.7% respectively. Conclusion We achieved promising results with this computer-aided diagnosis method that we tried to develop using convolutional neural networks based on transfer learning. This method can help clinicians for the diagnosis of hip osteoarthritis while interpreting plain pelvic radiographs, also provides assistance for a second objective interpretation. It may also reduce the need for advanced imaging methods in the diagnosis of hip osteoarthritis.