Unveiling the Strain Uniformity Challenge: Design and Evaluation of a Pdms Membrane for Precise Mechanobiology Studies
| dc.contributor.author | Duz, Nilufer | |
| dc.contributor.author | Gulsum, Yasin | |
| dc.contributor.author | Odeibat, Waleed | |
| dc.contributor.author | Uyanik, Ismail | |
| dc.contributor.author | Akar, Samet | |
| dc.contributor.author | Dincer, Pervin | |
| dc.date.accessioned | 2025-06-05T21:56:34Z | |
| dc.date.available | 2025-06-05T21:56:34Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Mechanotransduction and mechanosensing enable cells to respond to mechanical stimuli, essential in various physiological functions. Specialized cell stretching devices use stretchable, transparent, and biocompatible elastomeric membranes to study these responses. However, achieving strain uniformity is a key challenge, affecting data accuracy and reliability. This study designed a polydimethylsiloxane (PDMS) membrane with optimized uniformity for electromechanical cell stretching. Finite element analysis optimized membrane size and shape, achieving a 90% strain uniformity index-a 233% improvement over commercial membranes. By tailoring material properties like cross-linker ratio and curing time, membrane failure issues were resolved, enhancing applications in tissue engineering and mechanobiology research. | en_US |
| dc.description.sponsorship | Hacettepe University Scientific Research Projects Coordination Unit | en_US |
| dc.description.sponsorship | We would like to acknowledge the use of ChatGPT (version 4) for typo and grammar check. | en_US |
| dc.identifier.doi | 10.1080/10255842.2025.2495254 | |
| dc.identifier.issn | 1025-5842 | |
| dc.identifier.issn | 1476-8259 | |
| dc.identifier.scopus | 2-s2.0-105004040552 | |
| dc.identifier.uri | https://doi.org/10.1080/10255842.2025.2495254 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12416/10134 | |
| dc.language.iso | en | en_US |
| dc.publisher | Taylor & Francis Ltd | en_US |
| dc.relation.ispartof | Computer Methods in Biomechanics and Biomedical Engineering | |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Biaxial Tension | en_US |
| dc.subject | Hyperelastic Material | en_US |
| dc.subject | Pdms | en_US |
| dc.subject | Uniform Strain | en_US |
| dc.title | Unveiling the Strain Uniformity Challenge: Design and Evaluation of a Pdms Membrane for Precise Mechanobiology Studies | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.wosid | Uyanik, Ismail/Mbg-5350-2025 | |
| gdc.author.wosid | Oliaei, Samad/Aaw-1891-2020 | |
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| gdc.description.department | Çankaya University | en_US |
| gdc.description.departmenttemp | [Duz, Nilufer; Dincer, Pervin] Hacettepe Univ, Fac Med, Dept Med Biol, Ankara, Turkiye; [Gulsum, Yasin; Odeibat, Waleed; Akar, Samet] Cankaya Univ, Fac Engn, Dept Mech Engn, TR-6800 Ankara, Turkiye; [Duz, Nilufer; Uyanik, Ismail] Hacettepe Univ, Fac Engn, Dept Elect & Elect Engn, Ankara, Turkiye | en_US |
| gdc.description.endpage | 13 | |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.identifier.pmid | 40302214 | |
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